In clinical transplantation, the majority of solid organs is derived from brain dead (BD) donors. BD results in a number of pathophysiological changes including hemodynamic instability, hormone dysregulation, enhanced leukocyte infiltration and induction of inflammatory cytokines. Overall, this inflammation exacerbates ischemia reperfusion injury (IRI) therefore influencing graft survival in the long-term. We investigate the impact of BD on various solid organs and develop treatment schemes in order to ameliorate BD and IRI associated injury.