Publications

2018

Graft Pre-conditioning by Peri-Operative Perfusion of Kidney Allografts With Rabbit Anti-human T-lymphocyte Globulin Results in Improved Kidney Graft Function in the Early Post-transplantation Period-a Prospective, Randomized Placebo-Controlled Trial.

Ritschl PV, Günther J, Hofhansel L, Kühl AA, Sattler A, Ernst S, Friedersdorff F, Ebner S, Weiss S, Bösmüller C, Weissenbacher A, Oberhuber R, Cardini B, Öllinger R, Schneeberger S, Biebl M, Denecke C, Margreiter C, Resch T, Aigner F, Maglione M, Pratschke J, Kotsch K.

Front Immunol. 2018 Aug 24;9:1911

2017

Deletion of the Activating NK Cell Receptor NKG2D Accelerates Rejection of Cardiac Allografts

Fabritius C, Ritschl PV, Resch T, Roth M, Ebner S, Günther J, Mellitzer V, Nguyen AV, Pratschke J, Sauter M, Klingel K and Kotsch K.

Am J Transplant. Accepted manuscript online: 14 AUG 2017 04:50AM EST | DOI: 10.1111/ajt.14467

Disturbances in iron homeostasis result in accelerated rejection after experimental heart transplantation.

Resch T, Ashraf MI, Ritschl PV, Ebner S, Fabritius C, Brunner A, Schäfer G, Regele H, Günther J, Weiss G, Kotsch K.

J Heart Lung Transplant. 2017 Mar 7. pii: S1053-2498(17)31681-9.

Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome.

Günther J, Resch T, Hackl H, Sattler A, Ebner S, Ritschl PV, Biebl M, Öllinger R, Schneeberger S, Brandacher G, Schwelberger H, Zelger B, Stauch D, Pascher A, Pratschke J, Kotsch K.

Kidney Int. 2017 Feb 20. pii: S0085-2538(17)30002-9.

2016

Cell-penetrating self-nanoemulsifying drug delivery systems (SNEDDS) for oral gene delivery.

Mahmood A, Prüfert F, Efiana NA, Ashraf MI, Hermann M, Hussain S, Bernkop-Schnürch A.

Expert Opin Drug Deliv. 2016 Nov;13(11):1503-1512.

Evolution of graft morphology and function after recellularization of decellularized rat livers.

Butter A, Aliyev K, Hillebrandt KH, Raschzok N, Kluge M, Seiffert N, Tang P, Napierala H, Ashraf MI, Reutzel-Selke A, Andreou A, Pratschke J, Sauer IM, Struecker B.

J Tissue Eng Regen Med. 2016 Dec 13. doi: 10.1002/term.2383.

Donor brain death leads to differential immune activation in solid organs but does not accelerate ischaemia-reperfusion injury.

Ritschl PV, Ashraf MI, Oberhuber R, Mellitzer V, Fabritius C, Resch T, Ebner S, Sauter M, Klingel K, Pratschke J, Kotsch K.

J Pathol. 2016 May;239(1):84-96.

Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation.

Ashraf MI, Schwelberger HG, Brendel KA, Feurle J, Andrassy J, Kotsch K, Regele H, Pratschke J, Maier HT, Aigner F.

Am J Transplant. 2016 Mar;16(3):808-20.

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.

Khalid S, Drasche A, Thurner M, Hermann M, Ashraf MI, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J.

Sci Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930.

Biopsychronology: A Method Using Live Tissue Staining to Image Cell Function in the Kidney.

Ashraf MI, Fries D, Streif W, Aigner F, Hengster P, Troppmair J, Hermann M.

Methods Mol Biol. 2016;1397:81-90. doi: 10.1007/978-1-4939-3353-2_8.

2015

Treatment with tetrahydrobiopterin overcomes brain death-associated injury in a murine model of pancreas transplantation.

Oberhuber R, Ritschl P, Fabritius C, Nguyen AV, Hermann M, Obrist P, Werner ER, Maglione M, Flörchinger B, Ebner S, Resch T, Pratschke J, Kotsch K.

Am J Transplant. 2015 Nov;15(11):2865-76. doi: 10.1111/ajt.13364. Epub 2015 Jun 23.

IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions.

Sattler A, Dang-Heine C, Reinke P, Babel N.

Eur J Immunol. 2015 Aug;45(8):2286-98

The Role of Natural Killer Cells in Humoral Rejection.

Resch T, Fabritius C, Ebner S, Ritschl P, Kotsch K.

Transplantation. 2015 Jul;99(7):1335-40. doi: 10.1097/TP.0000000000000757. Review.

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice†.

Tepeköylü C, Lobenwein D, Blunder S, Kozaryn R, Dietl M, Ritschl P, Pechriggl EJ, Blumer MJ, Bitsche M, Schistek R, Kotsch K, Fritsch H, Grimm M, Holfeld J.

Eur J Cardiothorac Surg. 2015 Mar;47(3):e80-90. doi: 10.1093/ejcts/ezu428. Epub 2014 Nov 24.

2014

Report of the joint ESOT and TTS basic science meeting 2013: current concepts and discoveries in translational transplantation.

Ebner S, Fabritius C, Ritschl P, Oberhuber R, Günther J, Kotsch K.

Transpl Int. 2014 Oct;27(10):987-93. doi: 10.1111/tri.12366. Epub 2014 Jun 30. Review.

The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy.

Klingel K, Fabritius C, Sauter M, Göldner K, Stauch D, Kandolf R, Ettischer N, Gahlen S, Schönberger T, Ebner S, Makrigiannis AP, Bélanger S, Diefenbach A, Polić B, Pratschke J, Kotsch K.

J Pathol. 2014 Oct;234(2):164-77. doi: 10.1002/path.4369. Epub 2014 Aug 6.

NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.

Sleiman M, Brons NH, Kaoma T, Dogu F, Villa-Forte A, Lenoble P, Hentges F, Kotsch K, Gadola SD, Vilches C, Zimmer J.

J Immunol. 2014 Mar 15;192(6):2602-10. doi: 10.4049/jimmunol.1302843. Epub 2014 Feb 19.

Biopsychronology: live confocal imaging of biopsies to assess organ function.

Ashraf MI, Fries D, Streif W, Aigner F, Hengster P, Troppmair J, Hermann M.

Transpl Int. 2014 Aug;27(8):868-76. doi: 10.1111/tri.12338.

Differential influenza H1N1-specific humoral and cellular response kinetics in kidney transplant patients.

Rambal V, Müller K, Dang-Heine C, Sattler A, Dziubianau M, Weist B, Luu SH, Stoyanova A, Nickel P, Thiel A, Neumann A, Schweiger B, Reinke P, Babel N.

Med Microbiol Immunol. 2014 Feb;203(1):35-45

Bilirubin rinse of the graft ameliorates ischemia reperfusion injury in heart transplantation.

Bösch F, Thomas M, Kogler P, Oberhuber R, Sucher R, Aigner F, Semsroth S, Wiedemann D, Yamashita K, Troppmair J, Kotsch K, Pratschke J, Öllinger R.

Transpl Int. 2014 May;27(5):504-13. doi: 10.1111/tri.12278. Epub 2014 Mar 5.

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.

Ashraf MI, Ebner M, Wallner C, Haller M, Khalid S, Schwelberger H, Koziel K, Enthammer M, Hermann M, Sickinger S, Soleiman A, Steger C, Vallant S, Sucher R, Brandacher G, Santer P, Dragun D, Troppmair J.

Cell Commun Signal. 2014 Jan 14;12:6. doi: 10.1186/1478-811X-12-6.

2013

Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.

Enthammer M, Papadakis ES, Salomé Gachet M, Deutsch M, Schwaiger S, Koziel K, Ashraf MI, Khalid S, Wolber G, Packham G, Cutress RI, Stuppner H, Troppmair J.

Mol Cancer Ther. 2013 Nov;12(11):2400-14. doi: 10.1158/1535-7163.MCT-13-0142.

RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.

Koziel K, Smigelskaite J, Drasche A, Enthammer M, Ashraf MI, Khalid S, Troppmair J.

Exp Cell Res. 2013 Oct 15;319(17):2728-38. doi: 10.1016/j.yexcr.2013.07.029.

Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

Alexander T, Sattler A, Templin L, Kohler S, Groß C, Meisel A, Sawitzki B, Burmester GR, Arnold R, Radbruch A, Thiel A, Hiepe F.

Ann Rheum Dis. 2013 Sep 1;72(9):1549-58

Targeting the Kv1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study.

Hautz T, Krapf C, Grahammer J, Zelger B, Hickethier T, Seger C, Eberhart N, Wallner C, Messner F, Kotsch K, Griesmacher A, Brandacher G, Lee WP, Margreiter R, Pratschke J, Glossmann H, Schneeberger S.

Transpl Int. 2013 May;26(5):552-61. doi: 10.1111/tri.12080. Epub 2013 Mar 15.

The genetic predisposition of natural killer cell to BK virus-associated nephropathy in renal transplant patients.

Trydzenskaya H, Juerchott K, Lachmann N, Kotsch K, Kunert K, Weist B, Schönemann C, Schindler R, Nickel P, Melzig MF, Hugo C, Thomusch O, Neumann AU, Reinke P, Babel N.

Kidney Int. 2013 Aug;84(2):359-65. doi: 10.1038/ki.2013.59. Epub 2013 Mar 13.

Adiponectin modulates NK-cell function.

Wilk S, Jenke A, Stehr J, Yang CA, Bauer S, Göldner K, Kotsch K, Volk HD, Poller W, Schultheiss HP, Skurk C, Scheibenbogen C.

Eur J Immunol. 2013 Apr;43(4):1024-33. doi: 10.1002/eji.201242382. Epub 2013 Mar 1.

Synergistic effects of prolonged warm ischemia and donor age on the immune response following donation after cardiac death kidney transplantation.

Denecke C, Yuan X, Ge X, Kim IK, Bedi D, Boenisch O, Weiland A, Jurisch A, Kotsch K, Pratschke J, Reutzel-Selke A, Tullius SG.

Surgery. 2013 Feb;153(2):249-61. doi: 10.1016/j.surg.2012.07.035. Epub 2012 Oct 9.

2012

Decreased levels of serum complement C3 and natural killer cells add to the predictive value of total immunoglobulin G for severe infection in heart transplant recipients.

Sarmiento E, del Pozo N, Gallego A, Fernández-Yañez J, Palomo J, Villa A, Ruiz M, Muñoz P, Rodríguez C, Rodríguez-Molina J, Navarro J, Kotsch K, Fernandez-Cruz E, Carbone J.

Transpl Infect Dis. 2012 Oct;14(5):526-39. doi: 10.1111/j.1399-3062.2012.00757.x.

Induction of bona fide regulatory T cells after liver transplantation - the potential influence of polyclonal antithymocyte globulin.

Stauch D, Yahyazadeh A, Bova R, Melloh GC, Füldner A, Baron U, Olek S, Göldner K, Weiss S, Pratschke J, Kotsch K.

Transpl Int. 2012 Mar;25(3):302-13. doi: 10.1111/j.1432-2277.2011.01405.x. Epub 2011 Dec 21.

2011

Novel approach for improved assessment of phenotypic and functional characteristics of BKV-specific T-cell immunity.

Trydzenskaya H, Sattler A, Müller K, Schachtner T, Dang-Heine C, Friedrich P, Nickel P, Hoerstrup J, Schindler R, Thiel A, Melzig MF, Reinke P, Babel N.

Transplantation. 2011 Dec 15;92(11):1269-77

In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemia.

Hara Y, Stolk M, Ringe J, Dehne T, Ladhoff J, Kotsch K, Reutzel-Selke A, Reinke P, Volk HD, Seifert M.

Transpl Int. 2011 Nov;24(11):1112-23. doi: 10.1111/j.1432-2277.2011.01328.x. Epub 2011 Aug 31.

Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy.

Noutsias M, Rohde M, Göldner K, Block A, Blunert K, Hemaidan L, Hummel M, Blohm JH, Lassner D, Kühl U, Schultheiss HP, Volk HD, Kotsch K.

Eur J Heart Fail. 2011 Jun;13(6):611-8. doi: 10.1093/eurjhf/hfr014. Epub 2011 Mar 19.

Prolonged brain death duration--does it improve graft quality? Invited commentary on Nijboer et al.

Kunert K, Weiss S, Kotsch K, Pratschke J.

Transpl Int. 2011 Jan;24(1):12-3.

BK-VP3 as a new target of cellular immunity in BK virus infection.

Mueller K, Schachtner T, Sattler A, Meier S, Friedrich P, Trydzenskaya H, Hinrichs C, Trappe R, Thiel A, Reinke P, Babel N.

Transplantation. 2011 Jan 15;91(1):100-7

2010

Novel markers in zero-hour kidney biopsies indicate graft quality and clinical outcome.

Kotsch K, Kunert K, Merk V, Reutzel-Selke A, Pascher A, Fritzsche F, Tullius SG, Pratschke J.

Transplantation. 2010 Nov 15;90(9):958-65.

Perioperative gene expression analysis for prediction of postoperative sepsis.

Hinrichs C, Kotsch K, Buchwald S, Habicher M, Saak N, Gerlach H, Volk HD, Keh D.

Clin Chem. 2010 Apr;56(4):613-22. doi: 10.1373/clinchem.2009.133876. Epub 2010 Feb 4.

2009

Select item 19933937

Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor.

Pinkert S, Westermann D, Wang X, Klingel K, Dörner A, Savvatis K, Grössl T, Krohn S, Tschöpe C, Zeichhardt H, Kotsch K, Weitmann K, Hoffmann W, Schultheiss HP, Spiller OB, Poller W, Fechner H.

Circulation. 2009 Dec 8;120(23):2358-66

Intracellular signaling pathways control mitochondrial events associated with the development of ischemia/ reperfusion-associated damage.

Sucher R, Gehwolf P, Kaier T, Hermann M, Maglione M, Oberhuber R, Ratschiller T, Kuznetsov AV, Bösch F, Kozlov AV, Ashraf MI, Schneeberger S, Brandacher G, Ollinger R, Margreiter R, Troppmair J.

Transpl Int. 2009 Sep;22(9):922-30. doi: 10.1111/j.1432-2277.2009.00883.x

Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis.

Jäkel S, Kuckelkorn U, Szalay G, Plötz M, Textoris-Taube K, Opitz E, Klingel K, Stevanovic S, Kandolf R, Kotsch K, Stangl K, Kloetzel PM, Voigt A.

Am J Pathol. 2009 Aug;175(2):510-8. doi: 10.2353/ajpath.2009.090033. Epub 2009 Jul 9.

Role of NK and NKT cells in solid organ transplantation.

Pratschke J, Stauch D, Kotsch K.

Transpl Int. 2009 Sep;22(9):859-68. doi: 10.1111/j.1432-2277.2009.00884.x. Epub 2009 Apr 21. Review.

Cold ischemia does not interfere with tolerance induction.

Reutzel-Selke A, Hartmann J, Brandenburg P, Jurisch A, Francuski M, Ulrich F, Kotsch K, Pascher A, Neuhaus P, Tullius SG, Pratschke J.

Transplantation. 2009 Apr 27;87(8):1116-24. doi: 10.1097/TP.0b013e31819dfb29

Targeting of natural killer cells by rabbit antithymocyte globulin and campath-1H: similar effects independent of specificity.

Stauch D, Dernier A, Sarmiento Marchese E, Kunert K, Volk HD, Pratschke J, Kotsch K.

PLoS One. 2009;4(3):e4709. doi: 10.1371/journal.pone.0004709. Epub 2009 Mar 5.

Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.

Wieczorek G, Asemissen A, Model F, Turbachova I, Floess S, Liebenberg V, Baron U, Stauch D, Kotsch K, Pratschke J, Hamann A, Loddenkemper C, Stein H, Volk HD, Hoffmüller U, Grützkau A, Mustea A, Huehn J, Scheibenbogen C, Olek S.

Cancer Res. 2009 Jan 15;69(2):599-608. doi: 10.1158/0008-5472.CAN-08-2361.

Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation.

Sattler A, Wagner U, Rossol M, Sieper J, Wu P, Krause A, Schmidt WA, Radmer S, Kohler S, Romagnani C, Thiel A.

Blood. 2009 Feb 26;113(9):1948-56

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system.

Alexander T, Thiel A, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, Arnold R, Radbruch A, Hiepe F.

Blood. 2009 Jan 1;113(1):214-23

Select item 19136659

SHIP limits immunoregulatory capacity in the T-cell compartment.

Collazo MM, Wood D, Paraiso KH, Lund E, Engelman RW, Le CT, Stauch D, Kotsch K, Kerr WG.

Blood. 2009 Mar 26;113(13):2934-44. doi: 10.1182/blood-2008-09-181164.

Amplifying the fluorescence of bilirubin enables the real-time detection of heme oxygenase activity.

Klemz R, Mashreghi MF, Spies C, Volk HD, Kotsch K.

Free Radic Biol Med. 2009 Jan 15;46(2):305-11.

2008

Select item 19092349

Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial.

Kotsch K, Ulrich F, Reutzel-Selke A, Pascher A, Faber W, Warnick P, Hoffman S, Francuski M, Kunert C, Kuecuek O, Schumacher G, Wesslau C, Lun A, Kohler S, Weiss S, Tullius SG, Neuhaus P, Pratschke J.

Ann Surg. 2008 Dec;248(6):1042-50.

NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy.

Streitz M, Noutsias M, Volkmer R, Rohde M, Brestrich G, Block A, Klippert K, Kotsch K, Ay B, Hummel M, Kühl U, Lassner D, Schultheiss HP, Volk HD, Kern F.

PLoS One. 2008 Jun 4;3(6):e2361. doi: 10.1371/journal.pone.0002361.

Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3.

Mashreghi MF, Klemz R, Knosalla IS, Gerstmayer B, Janssen U, Buelow R, Jozkowicz A, Dulak J, Volk HD, Kotsch K.

Ischemic preconditioning produces systemic protective and adoptively transferable effects.

Reutzel-Selke A, Pratschke J, Martins PN, Denecke C, Jurisch A, Kotsch K, Pascher A, Neuhaus P, Tullius SG.

Kidney Int. 2008 Sep;74(5):622-30. doi: 10.1038/ki.2008.208. Epub 2008 May 28.

Preamplification techniques for real-time RT-PCR analyses of endomyocardial biopsies.

Noutsias M, Rohde M, Block A, Klippert K, Lettau O, Blunert K, Hummel M, Kühl U, Lehmkuhl H, Hetzer R, Rauch U, Poller W, Pauschinger M, Schultheiss HP, Volk HD, Kotsch K.

BMC Mol Biol. 2008 Jan 14;9:3. doi: 10.1186/1471-2199-9-3.

2007

KIR/HLA ligand incompatibility in kidney transplantation.

Kunert K, Seiler M, Mashreghi MF, Klippert K, Schönemann C, Neumann K, Pratschke J, Reinke P, Volk HD, Kotsch K.

Transplantation. 2007 Dec 15;84(11):1527-33.

Heme oxygenase-1 ameliorates ischemia/reperfusion injury by targeting dendritic cell maturation and migration.

Kotsch K, Martins PN, Klemz R, Janssen U, Gerstmayer B, Dernier A, Reutzel-Selke A, Kuckelkorn U, Tullius SG, Volk HD.

Antioxid Redox Signal. 2007 Dec;9(12):2049-63.

Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice.

Kökény G, Godó M, Nagy E, Kardos M, Kotsch K, Casalis P, Bodor C, Rosivall L, Volk HD, Zenclussen AC, Hamar P.

Lupus. 2007;16(7):465-77.

Intrarenal cytokine and chemokine gene expression and kidney graft outcome.

Hribova P, Lacha J, Kotsch K, Volk HD, Brabcova I, Skibova J, Vitko S, Viklicky O.

Kidney Blood Press Res. 2007;30(5):273-82. Epub 2007 Jul 4.

Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation.

Weiss S, Kotsch K, Francuski M, Reutzel-Selke A, Mantouvalou L, Klemz R, Kuecuek O, Jonas S, Wesslau C, Ulrich F, Pascher A, Volk HD, Tullius SG, Neuhaus P, Pratschke J.

Am J Transplant. 2007 Jun;7(6):1584-93. Epub 2007 Apr 8.